Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 7/20 | 0.84 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.84 |
| ▸ | CMA1 | P23946 | 1/20 | 0.84 |
| ▸ | F7 | P08709 | 1/20 | 0.84 |
| ▸ | LTA4H | P09960 | 1/20 | 0.84 |
| ▸ | F3 | P13726 | 1/20 | 0.84 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | F11 | P03951 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL405311 | 0.92 | AHR (1.00) | AHRNR4A2CMA1F7LTA4H | |
| SCHEMBL30587351 | 0.92 | AHR (1.00) | AHRNR4A2CMA1F7LTA4H | |
| SCHEMBL29990254 | 0.92 | AHR (1.00) | AHRNR4A2CMA1F7LTA4H | |
| SCHEMBL75475 | 0.92 | AHR (1.00) | AHRNR4A2CMA1F7LTA4H | |
| Methane SCHEMBL27929622 | 0.90 | AHR (0.95) | AHRNR4A2CMA1F7LTA4H | |
| Hydrogen Sulfide SCHEMBL28281607 | 0.90 | AHR (0.95) | AHRNR4A2CMA1F7LTA4H | |
| SCHEMBL27701627 | 0.90 | AHR (0.95) | AHRNR4A2CMA1F7LTA4H | |
| Methane SCHEMBL27929624 | 0.90 | AHR (0.95) | AHRNR4A2CMA1F7LTA4H | |
| SCHEMBL8185932 | 0.88 | AHR (0.70) | AHRNR4A2CMA1F7LTA4H | |
| Indole SCHEMBL28309073 | 0.86 | AHR (0.81) | AHRNR4A2CMA1F7LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |
| US-20030055097-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055097-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP3K1 | AHR 3982/4885NR4A2 3494/4885CMA1 2867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.