Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003729 | 0.85 | EGFR (0.73) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL6977418 | 0.79 | EGFR (0.75) | EGFRERBB2ERBB4GAKERBB3 | |
| SCHEMBL4009625 | 0.73 | EGFR (0.72) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL4002290 | 0.73 | EGFR (0.62) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL28771965 | 0.73 | EGFR (0.82) | EGFRERBB2ERBB4HDAC3ABL1 | |
| SCHEMBL4003728 | 0.73 | EGFR (0.51) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL2306317 | 0.72 | EGFR (0.63) | EGFRERBB2ERBB4HDAC3ABL1 | |
| SCHEMBL6954796 | 0.72 | EGFR (0.84) | EGFRERBB2ERBB4HDAC3ABL1 | |
| SCHEMBL6355635 | 0.72 | EGFR (0.55) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL3702763 | 0.72 | EGFR (0.77) | EGFRERBB2ERBB4HDAC3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6933299-B1 | Anilinoquinazolines as protein tyrosine kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-23 | — | — | US | disclosed |