Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.62 |
| ▸ | CCND1 | P24385 | 20/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 18/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 18/20 | 0.62 |
| ▸ | CDK2 | P24941 | 18/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | STK16 | O75716 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | ERCC2 | P18074 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6351396 | 0.97 | CDK4 (0.59) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6349662 | 0.94 | CDK4 (0.54) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6342960 | 0.94 | CDK4 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6350895 | 0.92 | CDK4 (0.66) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6340975 | 0.91 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6338348 | 0.91 | CDK4 (0.64) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6341295 | 0.91 | CDK4 (0.64) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6343822 | 0.89 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6339631 | 0.88 | CDK4 (0.59) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6339613 | 0.88 | CDK4 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020091127-A1 | Semicarbazides and their uses | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-07-11 | — | — | US | claimed |
| US-6849631-B2 | Semicarbazides and their uses | BRISTOL MYERS SQUIBB PHARMA COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| US-20020091127-A1 | Semicarbazides and their uses | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091127-A1 | Semicarbazides and their uses | CDK1, CCNA1, CDK17 | CDK4 12/4885CCND1 37/4885CCNE2 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.