Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Int131. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 20/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Int131 SCHEMBL634767 | 0.99 | PPARG (1.00) | PPARGCYP3A4 | |
| Int131 SCHEMBL30035369 | 0.99 | PPARG (1.00) | PPARGCYP3A4 | |
| Int131 SCHEMBL29404335 | 0.99 | PPARG (1.00) | PPARGCYP3A4 | |
| SCHEMBL24268600 | 0.92 | PPARG (0.87) | PPARGCYP3A4 | |
| SCHEMBL22515346 | 0.92 | PPARG (0.87) | PPARGCYP3A4 | |
| Int131 SCHEMBL634435 | 0.92 | PPARG (0.86) | PPARGCYP3A4 | |
| SCHEMBL22515271 | 0.91 | PPARG (0.84) | PPARGCYP3A4 | |
| SCHEMBL22203939 | 0.90 | PPARG (0.83) | PPARGCYP3A4 | |
| SCHEMBL7996313 | 0.90 | PPARG (0.83) | PPARGCYP3A4 | |
| SCHEMBL25819017 | 0.90 | PPARG (0.82) | PPARGCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677797-B1 | SALTS AND POLYMORPHS OF A POTENT ANTIDIABETIC COMPOUND | AMGEN INC (US) | 2012-02-22 | — | — | EP | claimed |