Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772642 | 0.99 | SYK (0.46) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| Hydrochloric Acid SCHEMBL4763304 | 0.98 | SYK (0.45) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| SCHEMBL6350846 | 0.93 | SYK (0.41) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4775455 | 0.90 | GBA1 (0.42) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4773670 | 0.89 | GBA1 (0.44) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| SCHEMBL6350844 | 0.89 | KMT2A (0.39) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| Hydrochloric Acid SCHEMBL4772791 | 0.89 | GBA1 (0.41) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4767884 | 0.89 | GBA1 (0.41) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| Hydrochloric Acid SCHEMBL4773842 | 0.88 | GBA1 (0.43) | SYKGBA1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4763994 | 0.88 | GBA1 (0.46) | SYKGBA1SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875761-B2 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. (JP) | 2005-04-05 | — | — | US | disclosed |