Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 18/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 14/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.50 |
| ▸ | PI4KA | P42356 | 2/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6344566 | 0.78 | PI4KA (0.48) | ADORA2AADORA1ADORA2BADORA3PI4KA | |
| SCHEMBL30974263 | 0.77 | ADORA2A (0.47) | ADORA2AADORA1ADORA2BADORA3PI4KA | |
| SCHEMBL27422698 | 0.77 | ADORA2A (0.47) | ADORA2AADORA1ADORA2BADORA3PI4KA | |
| SCHEMBL6215848 | 0.76 | PI4KA (0.51) | ADORA2AADORA1ADORA2BADORA3PI4KA | |
| SCHEMBL6354390 | 0.75 | PI4KA (0.69) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL1755068 | 0.68 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3PI4KA | |
| SCHEMBL29439771 | 0.67 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3PI4KA | |
| SCHEMBL8832637 | 0.67 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3PI4KA | |
| SCHEMBL4142807 | 0.66 | TLR7 (0.41) | ADORA2AADORA2B | |
| SCHEMBL10379475 | 0.66 | ADORA2A (0.68) | ADORA2AADORA1ADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6841549-B1 | Condensed imidazole compounds and a therapeutic agent for diabetes mellitus | EISAI CO., LTD. (JP) | 2005-01-11 | — | — | US | disclosed |
| EP-1221444-A1 | FUSED IMIDAZOLE COMPOUNDS AND REMEDIES FOR DIABETES MELLITUS | Eisai Co., Ltd. (JP) | 2002-07-10 | — | — | EP | disclosed |