SCHEMBL6358738

SCHEMBL6358738

CC1=C(CC(=O)O)c2ccccc2/C1=C/c1ccc([S+](C)[O-])cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 14/20 0.58
RXRA P19793 6/20 0.58
CYP1A2 P05177 3/20 0.52
MAPT P10636 3/20 0.52
MAPK1 P28482 3/20 0.52
TDP1 Q9NUW8 2/20 0.52
CYP3A4 P08684 2/20 0.52
PMP22 Q01453 2/20 0.52
NPSR1 Q6W5P4 2/20 0.52
GLA P06280 1/20 0.52
TSHR P16473 1/20 0.52
EDNRA P25101 1/20 0.52
HIF1A Q16665 1/20 0.52
HSD17B10 Q99714 1/20 0.52
PTGS2 P35354 2/20 0.50
EGFR P00533 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
DRD1 P21728 1/20 0.50
PTGS1 P23219 1/20 0.50
OPRM1 P35372 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11725365 1.00 PPARG (0.58) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL2541626 0.89 PPARG (0.46) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL2220382 0.88 PPARG (0.60) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL7937481 0.88 PPARG (0.56) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL8683612 0.87 PPARG (0.59) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL2224246 0.87 PPARG (0.59) PPARGRXRACYP1A2MAPTMAPK1
Sulindac SCHEMBL2029754 0.86 PPARG (0.78) PPARGRXRACYP1A2MAPTMAPK1
SCHEMBL7632785 0.86 PPARG (0.58) PPARGRXRACYP1A2MAPTMAPK1
Sulindac Sulfoxide SCHEMBL11255653 0.86 PPARG (0.78) PPARGRXRACYP1A2MAPTMAPK1
Sulindac SCHEMBL4202 0.86 PPARG (0.78) PPARGRXRACYP1A2MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9243024-B2 Aptamer-mediated drug release THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2016-01-26 US disclosed
US-20120114558-A1 APTAMER-MEDIATED DRUG RELEASE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-05-10 US disclosed
US-4030994-A FLUOROXY PENTAFLUOROSULFUR MERCK & CO., INC. (US) 1977-06-21 US disclosed