Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779482 | 0.92 | MCHR1 (0.47) | HTR2AHTR2CHTR2BATMTOP2A | |
| SCHEMBL5055858 | 0.92 | MCHR1 (0.47) | HTR2AHTR2CHTR2BATMTOP2A | |
| SCHEMBL5050630 | 0.89 | HTR2A (0.53) | HTR2AHTR2CHTR2BATMMEN1 | |
| SCHEMBL5636335 | 0.89 | HTR2A (0.53) | HTR2AHTR2CHTR2BATMMEN1 | |
| SCHEMBL6365668 | 0.81 | ATM (0.47) | ATMCA1CA2ACHETACR3 | |
| SCHEMBL7008755 | 0.79 | CA1 (0.46) | HTR2AHTR2CHTR2BATMCA1 | |
| SCHEMBL4951396 | 0.77 | ATM (0.43) | HTR2AHTR2CHTR2BATMTOP2A | |
| SCHEMBL5637368 | 0.77 | ATM (0.43) | HTR2AHTR2CHTR2BATMTOP2A | |
| SCHEMBL14274480 | 0.77 | PREP (0.43) | ATMMEN1KMT2ATOP2ATOP2B | |
| SCHEMBL3962356 | 0.77 | ATM (0.43) | HTR2AHTR2CHTR2BATMTOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956036-B1 | 6-hydroxy-indazole derivatives for treating glaucoma | ALCON, INC. (CH) | 2005-10-18 | — | — | US | disclosed |