Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31032738 | 0.80 | PDPK1 (0.55) | DYRK1AALDH1A1HPGDITKKDM4E | |
| SCHEMBL1144940 | 0.80 | KDM4E (0.50) | DYRK1AALDH1A1HPGDLMNAITK | |
| SCHEMBL627808 | 0.80 | PDPK1 (0.55) | DYRK1AALDH1A1HPGDITKKDM4E | |
| SCHEMBL29919843 | 0.80 | KDM4E (0.50) | DYRK1AALDH1A1HPGDLMNAITK | |
| SCHEMBL6361114 | 0.79 | ITK (0.50) | DYRK1AALDH1A1HPGDLMNAITK | |
| SCHEMBL15792074 | 0.79 | ITK (0.47) | DYRK1AALDH1A1HPGDITKKDM4E | |
| SCHEMBL28264393 | 0.79 | ITK (0.47) | DYRK1AALDH1A1HPGDLMNAITK | |
| SCHEMBL17229809 | 0.76 | KDM4E (0.45) | DYRK1AALDH1A1HPGDITKKDM4E | |
| SCHEMBL10271452 | 0.76 | ITK (0.45) | DYRK1AALDH1A1HPGDITKKDM4E | |
| SCHEMBL5952442 | 0.76 | DYRK1A (0.54) | DYRK1AALDH1A1HPGDITKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956036-B1 | 6-hydroxy-indazole derivatives for treating glaucoma | ALCON, INC. (CH) | 2005-10-18 | — | — | US | disclosed |
| EP-1268438-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070702-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |