Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 7/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 3/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954210 | 0.82 | TAAR1 (0.76) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| SCHEMBL957041 | 0.82 | TAAR1 (0.72) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| Hydrazine SCHEMBL6368451 | 0.79 | TAAR1 (0.55) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| SCHEMBL954681 | 0.76 | TAAR1 (0.73) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| SCHEMBL17887605 | 0.74 | NISCH (0.61) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| SCHEMBL953620 | 0.73 | TAAR1 (0.68) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| SCHEMBL953100 | 0.73 | TAAR1 (0.62) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| SCHEMBL953714 | 0.73 | TAAR1 (0.79) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| SCHEMBL953713 | 0.71 | TAAR1 (1.00) | NISCHTAAR1ADRA2BADRA2CADRA2A | |
| SCHEMBL954827 | 0.70 | TAAR1 (0.68) | NISCHTAAR1ADRA2BADRA2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |