Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.69 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7934609 | 1.00 | PDE9A (0.69) | PDE9APDE1CPDE1B | |
| SCHEMBL6341174 | 0.89 | PDE9A (0.64) | PDE9APDE1CPDE1B | |
| SCHEMBL6338662 | 0.88 | PDE9A (0.63) | PDE9APDE1CPDE1B | |
| SCHEMBL6370639 | 0.87 | PDE9A (0.63) | PDE9APDE1CPDE1B | |
| SCHEMBL7940028 | 0.87 | PDE9A (0.63) | PDE9APDE1CPDE1B | |
| SCHEMBL12401038 | 0.85 | PDE9A (0.95) | PDE9APDE1C | |
| SCHEMBL12401308 | 0.84 | PDE9A (0.98) | PDE9APDE1C | |
| SCHEMBL7877451 | 0.83 | PDE9A (0.76) | PDE9APDE1CPDE1B | |
| SCHEMBL12401068 | 0.82 | PDE9A (1.00) | PDE9APDE1C | |
| SCHEMBL1664897 | 0.82 | PDE9A (1.00) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334684-B1 | PYRAZOLOPYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2017-08-02 | — | — | EP | disclosed |
| US-9079905-B2 | Compounds for the treatment of CNS disorders | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-20120115863-A1 | COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
| WO-2010026214-A1 | PYRAZOLOPYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115863-A1 | COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS | CNR1, CNR2, CHRM5 | PDE9A 1374/4885PDE1C 765/4885PDE1B 589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.