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Hydrocortisone

Hydrocortisone

SCHEMBL6370134

C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 3/20 1.00
▸ HIF1A Q16665 11/20 1.00
▸ HSD17B10 Q99714 5/20 1.00
▸ SERPINA6 P08185 4/20 1.00
▸ CYP3A4 P08684 4/20 1.00
▸ SMN1; SMN2 Q16637 4/20 1.00
▸ NR3C2 P08235 4/20 1.00
▸ CYP2C19 P33261 3/20 1.00
▸ PGR P06401 3/20 1.00
▸ KMT2A Q03164 2/20 1.00
▸ SHBG P04278 2/20 1.00
▸ NFKB1 P19838 2/20 1.00
▸ MAPT P10636 2/20 1.00
▸ LMNA P02545 3/20 0.80
▸ AR P10275 2/20 0.78
▸ CHRM1 P11229 1/20 0.78
▸ PMP22 Q01453 2/20 0.73
▸ TSHR P16473 2/20 0.73
▸ BLM P54132 1/20 0.73
▸ POLB P06746 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrocortisone SCHEMBL6932400 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL10261067 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL1688689 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL13046615 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL15114813 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL24900238 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL13202859 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL5699764 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL10292969 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2
Hydrocortisone SCHEMBL19465688 1.00 HIF1A (1.00) HIF1AHSD17B10SERPINA6CYP3A4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2978414-A1 COMPOSITION COMPRISING HYDROCORTISONE Diurnal Limited (GB) 2016-02-03 — — EP disclosed
WO-2014184525-A1 COMPOSITION COMPRISING HYDROCORTISONE DIURNAL LIMITED (GB) 2014-11-20 — — WO disclosed
EP-2780003-A1 TREATMENT OF ADRENAL INSUFFICIENCY Diurnal Limited (GB) 2014-09-24 — — EP disclosed
WO-2013072707-A1 TREATMENT OF ADRENAL INSUFFICIENCY DIURNAL LIMITED (GB) 2013-05-23 — — WO disclosed
WO-2005042736-A1 CELL CULTURE SUPPLEMENT FOR THE IN VITRO CULTIVATION OF CELLS AND A METHOD FOR CULTURING CELLS SLANICKA KRIEGER MICHAELA (CH) 2005-05-12 — — WO disclosed
US-5728823-A SELECTIVE SEPARATING MEDIA IN CHROMATOGRAPHY CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1998-03-17 — — US disclosed
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