Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10545706 | 0.81 | — | — | |
| SCHEMBL30390700 | 0.71 | — | — | |
| SCHEMBL242590 | 0.69 | — | — | |
| SCHEMBL3632234 | 0.69 | — | — | |
| SCHEMBL3101667 | 0.69 | — | — | |
| SCHEMBL59994 | 0.69 | — | — | |
| SCHEMBL421917 | 0.69 | — | — | |
| SCHEMBL852746 | 0.69 | — | — | |
| Bromide SCHEMBL6305657 | 0.69 | — | — | |
| SCHEMBL1293140 | 0.66 | TSHR (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939854-B2 | Peptide inhibitors of hepatitis C virus NS3 protease | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-09-06 | — | — | US | disclosed |
| US-6846806-B2 | Peptide inhibitors of Hepatitis C virus NS3 protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-01-25 | — | — | US | disclosed |
| US-20040147483-A1 | Peptide inhibitors of hepatitis C virus NS3 protease | PRIESTLEY E SCOTT (DE) | 2004-07-29 | — | — | US | disclosed |
| US-20020177725-A1 | Peptide inhibitors of hepatitis C virus NS3 protein | BRISTOL-MYERS SQUIBB COMPANY (FORMERLY D/B/A DUPONT PHARMACEUTICALS COMPANY) | 2002-11-28 | — | — | US | disclosed |
| EP-0295056-B1 | ANTI-INFLAMMATORY FURANONES | ALLERGAN, INC (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5134128-A | Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis | ALLERGAN, INC. (US) | 1992-07-28 | — | — | US | disclosed |
| CN-1031839-A | ANTI-INFLAMMATORY FURANONES | ALLERGAN INC (US) | 1989-03-22 | — | — | CN | disclosed |
| US-4347190-A | ORGANOLEPTIC | GIVAUDAN CORPORATION (US) | 1982-08-31 | — | — | US | disclosed |
| US-4255337-A | SUBSTITUTED HEXENYL TETRAHYDROFURAN | GIVAUDAN CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |