SCHEMBL6375412

SCHEMBL6375412

O=C(Nc1ccccc1)OCc1cn(-c2cc3nc(C(=O)O)c(=O)[nH]c3cc2Cl)cn1

nearest known ligand 0.78

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 2/20 0.69
GRIA2 P42262 2/20 0.69
GRIA3 P42263 2/20 0.69
GRIA4 P48058 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6377223 0.94 GRIA1 (0.79) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6377217 0.91 GRIA1 (0.58) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6380453 0.89 GRIA1 (0.68) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6605090 0.88 GRIA1 (0.88) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6594056 0.86 GRIA1 (0.51) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6378000 0.85 GRIA1 (0.65) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6382552 0.84 GRIA1 (0.62) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6382570 0.82 GRIA1 (0.55) GRIA1GRIA2GRIA3GRIA4
SCHEMBL1907885 0.82 GRIA1 (1.00) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6602295 0.82 GRIA1 (0.86) GRIA1GRIA2GRIA3GRIA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1156047-B1 6-SUBSTITUTED-7- HETEROQUINOXALINE CARBOXYLIC ACID DERIVATIVES AND ADDITION SALTS THEREOF AND PROCESSES FOR THE PREPARATION OF BOTH KYORIN SEIYAKU KK (JP) 2005-08-31 EP disclosed
US-6632813-B1 6-subtituted-7-heteroquinoxalinecarboxylic acid derivatives and addition salts thereof and processes for the preparation of both KYORIN PHARMACEUTICAL CO., LTD. (JP) 2003-10-14 US disclosed
EP-1156047-A1 6-SUBSTITUTED-7- HETEROQUINOXALINE CARBOXYLIC ACID DERIVATIVES AND ADDITION SALTS THEREOF AND PROCESSES FOR THE PREPARATION OF BOTH KYORIN PHARMACEUTICAL CO., LTD. (JP) 2001-11-21 EP disclosed