Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | ESRRA | P11474 | 7/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.51 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6375844 | 1.00 | EGFR (0.64) | EGFRMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6379909 | 0.91 | ESRRA (0.65) | EGFRMEN1MAPTKMT2AESRRA | |
| SCHEMBL6379899 | 0.91 | ESRRA (0.65) | EGFRMEN1MAPTKMT2AESRRA | |
| SCHEMBL6372564 | 0.89 | ESRRA (0.63) | EGFRMEN1MAPTKMT2AESRRA | |
| SCHEMBL6372570 | 0.89 | ESRRA (0.63) | EGFRMEN1MAPTKMT2AESRRA | |
| SCHEMBL6375942 | 0.86 | ESRRA (0.60) | MEN1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL6375944 | 0.86 | ESRRA (0.60) | MEN1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL6373841 | 0.85 | CSNK2A1 (0.78) | MEN1ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL6373838 | 0.85 | CSNK2A1 (0.78) | MEN1ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL6374555 | 0.84 | ESRRA (0.76) | EGFRMEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005072731-A1 | 3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS | X-CEPTOR THERAPEUTICS, INC. (US) | 2005-08-11 | — | — | WO | claimed |
| WO-2005072731-A1 | 3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS | X-CEPTOR THERAPEUTICS, INC. (US) | 2005-08-11 | — | — | WO | disclosed |