Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 19/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460966 | 1.00 | KCNH2 (0.70) | KCNH2 | |
| SCHEMBL5633512 | 0.82 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL4460979 | 0.81 | KCNH2 (0.69) | KCNH2 | |
| SCHEMBL6376805 | 0.81 | KCNH2 (0.69) | KCNH2 | |
| SCHEMBL4460971 | 0.81 | KCNH2 (0.69) | KCNH2 | |
| SCHEMBL5024624 | 0.80 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL5633525 | 0.78 | KCNH2 (0.82) | KCNH2 | |
| SCHEMBL4471340 | 0.75 | KCNH2 (0.67) | KCNH2 | |
| SCHEMBL5397555 | 0.75 | KCNH2 (0.67) | KCNH2 | |
| SCHEMBL5417258 | 0.75 | KCNH2 (0.67) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050165065-A1 | N-type calcium channel blockers | ZALICUS PHARMACEUTICALS LTD. (CA) | 2005-07-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165065-A1 | N-type calcium channel blockers | CACNA1B, CACNA1C, CACNA1D | KCNH2 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.