Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 20/20 | 0.79 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.75 |
| ▸ | MLNR | O43193 | 1/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.75 |
| ▸ | DRD2 | P14416 | 1/20 | 0.75 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.75 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.75 |
| ▸ | DRD1 | P21728 | 1/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.75 |
| ▸ | HTR2A | P28223 | 1/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.75 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30103459 | 1.00 | ESR1 (0.79) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL4165462 | 1.00 | ESR1 (0.79) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL22692809 | 0.99 | ESR1 (0.77) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL3419820 | 0.98 | ESR1 (0.82) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL3413818 | 0.97 | ESR1 (0.78) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL5973173 | 0.97 | ESR1 (0.82) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL3414356 | 0.97 | ESR1 (0.78) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL1546005 | 0.97 | ESR1 (0.82) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL3412644 | 0.97 | ESR1 (0.78) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL3416547 | 0.96 | ESR1 (0.79) | ESR1ESR2MLNRABCB11NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844047-B2 | Process for the preparation of bazedoxifene | ERREGIERRE S.P.A. (IT) | 2020-11-24 | — | — | US | claimed |
| CN-110627704-A | Preparation method of bazedoxifene | 艾瑞吉瑞股份公司 | 2019-12-31 | — | — | CN | claimed |
| EP-2252585-B1 | METHODS OF PREPARING POLYMORPHIC FORM A OF BAZEDOXIFENE ACETATE | WYETH LLC (US) | 2013-11-06 | — | — | EP | claimed |
| US-8569483-B2 | Process for the preparation of bazedoxifene acetate and intermediates thereof | Divi's Laboratories, Ltd. (IN) | 2013-10-29 | — | — | US | claimed |
| US-20120330008-A1 | NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | DIVI'S LABORATORIES LIMITED (IN) | 2012-12-27 | — | — | US | claimed |
| EP-2419406-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | Sandoz AG (CH) | 2012-02-22 | — | — | EP | claimed |
| WO-2010118997-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | SANDOZ AG (CH) | 2010-10-21 | — | — | WO | claimed |
| EP-2185510-A2 | NEW SALTS OF BAZEDOXIFENE | Zentiva, K.S. (CZ) | 2010-05-19 | — | — | EP | claimed |
| WO-2009012734-A2 | NEW SALTS OF BAZEDOXIFENE | ZENTIVA A.S. (CZ) | 2009-01-29 | — | — | WO | claimed |
| EP-1051179-B1 | ANTI-ESTROGEN PLUS PROGESTIN CONTAINING ORAL CONTRACEPTIVES | WYETH CORP (US) | 2005-09-14 | — | — | EP | claimed |
| US-6326392-B1 | ADMINISTERING MIXTURE | AMERICAN HOME PRODUCTS CORPORATION | 2001-12-04 | — | — | US | claimed |
| US-6326367-B1 | THERAPY FOR OVARIAN CANCER | AMERICAN HOME PRODUCTS CORPORATION | 2001-12-04 | — | — | US | claimed |
| EP-0802183-B1 | Estrogenic agents | AMERICAN HOME PROD (US) | 2001-10-10 | — | — | EP | claimed |
| US-20010021719-A1 | 2-phenyl-1- [4- (2-aminoethoxy) - benzyl] - indoles as estrogenic agents | WYETH | 2001-09-13 | — | — | US | claimed |
| US-6232307-B1 | 2-PHENYL-1-(4-(2-AMINOETHOXY)-BENZYL)-INDOLE COMPOUNDS USEFUL AS ESTROGENIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-15 | — | — | US | claimed |
| US-6225308-B1 | 2-PHENYL-1-(4-(2-AMINOETHOXY)-BENZYL)-INDOLE COMPOUNDS WHICH ARE USEFUL AS ESTROGENIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-01 | — | — | US | claimed |
| EP-1051179-A2 | ANTI-ESTROGEN PLUS PROGESTIN CONTAINING ORAL CONTRACEPTIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-15 | — | — | EP | claimed |
| US-5998402-A | OSTEOPOROSIS; CARDIOVASCULAR DISORDERS; ANTICANCER AGENTS;POSTMEMOPAUSE THERAPY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-07 | — | — | US | claimed |
| WO-1999024027-A2 | ANTI-ESTROGEN PLUS PROGESTIN CONTAINING ORAL CONTRACEPTIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-05-20 | — | — | WO | claimed |
| EP-0802183-A1 | Estrogenic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-10-22 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010021719-A1 | 2-phenyl-1- [4- (2-aminoethoxy) - benzyl] - indoles as estrogenic agents | ESR1, ESR2, GPER1 | ESR1 1/4885ESR2 2/4885MLNR 874/4885 |
| US-20120330008-A1 | NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | CYP19A1, HSD17B11, SULT1E1 | ESR1 37/4885ESR2 16/4885MLNR 1768/4885 |
| US-10844047-B2 | Process for the preparation of bazedoxifene | CYP19A1, CYP3A5, CYP4A11 | ESR1 29/4885ESR2 74/4885MLNR 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.