Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381528 | 0.90 | PARP1 (0.58) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6384736 | 0.90 | PIM1 (0.56) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6381105 | 0.89 | PARP1 (0.71) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6379356 | 0.87 | PARP1 (0.53) | PARP1HPSEPLA2G2AALOX15PTGS2 | |
| SCHEMBL6384512 | 0.85 | PARP1 (0.56) | PARP1HPSEPLA2G2AALOX15PTGS2 | |
| SCHEMBL6381589 | 0.85 | PARP1 (0.56) | PARP1HPSEPLA2G2AALOX15PTGS2 | |
| SCHEMBL6384729 | 0.85 | HPSE (0.53) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL7131923 | 0.84 | PARP1 (0.79) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6384519 | 0.83 | PARP1 (0.49) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6379799 | 0.83 | PARP1 (0.56) | PARP1MAP4K4PIM1PIM3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131301-B1 | 2-PHENYLBENZIMIDAZOLES AND 2-PHENYLINDOLES, AND PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2005-08-24 | — | — | EP | disclosed |