Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 3/20 | 0.54 |
| ▸ | PARP1 | P09874 | 13/20 | 0.47 |
| ▸ | DHODH | Q02127 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384304 | 0.89 | PARP1 (0.45) | HPSEPARP1DHODHTP53 | |
| SCHEMBL6384729 | 0.88 | HPSE (0.53) | HPSEPARP1DHODHKDM4ENPC1 | |
| SCHEMBL6382252 | 0.86 | PIM1 (0.53) | HPSEPARP1DHODHKDM4ENPC1 | |
| SCHEMBL6384512 | 0.84 | PARP1 (0.56) | HPSEPARP1DHODHHDAC3HDAC1 | |
| SCHEMBL6380062 | 0.83 | PARP1 (0.44) | HPSEPARP1DHODHTP53 | |
| SCHEMBL6379356 | 0.83 | PARP1 (0.53) | HPSEPARP1DHODHHDAC3HDAC1 | |
| SCHEMBL6381589 | 0.80 | PARP1 (0.56) | HPSEPARP1DHODHHDAC3HDAC1 | |
| SCHEMBL6383551 | 0.79 | PARP1 (0.71) | HPSEPARP1DHODHHDAC3HDAC1 | |
| SCHEMBL6590709 | 0.79 | PKN1 (0.66) | HPSEPARP1DHODHPARP2PLA2G2A | |
| SCHEMBL6380064 | 0.78 | PARP1 (0.54) | HPSEPARP1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131301-B1 | 2-PHENYLBENZIMIDAZOLES AND 2-PHENYLINDOLES, AND PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2005-08-24 | — | — | EP | disclosed |