Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 15/20 | 0.75 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.56 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6379018 | 1.00 | ESRRA (0.75) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6375877 | 0.93 | ESRRA (0.77) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6375882 | 0.93 | ESRRA (0.77) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6372813 | 0.92 | ESRRA (0.72) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6372811 | 0.92 | ESRRA (0.72) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6380193 | 0.92 | ESRRA (0.82) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6380198 | 0.92 | ESRRA (0.82) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6375895 | 0.90 | ESRRA (0.79) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6375892 | 0.90 | ESRRA (0.79) | ESRRACSNK2A1MEN1NPC1USP2 | |
| SCHEMBL6372875 | 0.90 | ESRRA (0.78) | ESRRACSNK2A1MEN1NPC1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005072731-A1 | 3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS | X-CEPTOR THERAPEUTICS, INC. (US) | 2005-08-11 | — | — | WO | disclosed |