Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 11/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384161 | 0.90 | EGFR (0.57) | EGFRERBB2KDM1ALRRK2 | |
| SCHEMBL6382495 | 0.82 | EGFR (0.47) | EGFRERBB2KDM1AMAP2K1RAF1 | |
| SCHEMBL6384857 | 0.82 | EGFR (0.52) | EGFRERBB2RAB9ALRRK2MAPT | |
| SCHEMBL6387025 | 0.81 | EGFR (0.47) | EGFRERBB2LRRK2ALDH3A1 | |
| SCHEMBL6386483 | 0.81 | SRC (0.52) | EGFRERBB2MEN1KMT2ALRRK2 | |
| SCHEMBL6383564 | 0.81 | EGFR (0.47) | EGFRERBB2MAP2K1RAF1LRRK2 | |
| SCHEMBL6383797 | 0.81 | EGFR (0.53) | EGFRERBB2KMT2ALRRK2 | |
| SCHEMBL6384817 | 0.80 | EGFR (0.54) | EGFRERBB2MEN1KMT2ALRRK2 | |
| SCHEMBL6383939 | 0.80 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL6385354 | 0.80 | EGFR (0.50) | EGFRERBB2KMT2ALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-B1 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | WYETH CORP (US) | 2005-11-02 | — | — | EP | claimed |
| EP-0973746-B1 | SUBSTITUTED 3-CYANO QUINOLINES | WYETH CORP (US) | 2003-09-24 | — | — | EP | claimed |