Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.86 |
| ▸ | FYN | P06241 | 2/20 | 0.86 |
| ▸ | EGFR | P00533 | 3/20 | 0.80 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.80 |
| ▸ | ABL1 | P00519 | 2/20 | 0.75 |
| ▸ | BCR | P11274 | 2/20 | 0.75 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.70 |
| ▸ | FLT1 | P17948 | 1/20 | 0.70 |
| ▸ | FLT4 | P35916 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382249 | 1.00 | SRC (0.86) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL5201099 | 0.92 | SRC (1.00) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL6383141 | 0.89 | EGFR (1.00) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL6381057 | 0.88 | SRC (0.76) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL6382257 | 0.88 | SRC (0.76) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL6384840 | 0.86 | SRC (0.85) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL6380759 | 0.86 | SRC (0.64) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL6383464 | 0.86 | SRC (0.64) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL6380183 | 0.85 | SRC (0.81) | SRCFYNEGFRERBB2ABL1 | |
| SCHEMBL6685924 | 0.85 | SRC (0.83) | SRCFYNEGFRERBB2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-B1 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | WYETH CORP (US) | 2005-11-02 | — | — | EP | claimed |
| EP-0973746-B1 | SUBSTITUTED 3-CYANO QUINOLINES | WYETH CORP (US) | 2003-09-24 | — | — | EP | claimed |
| US-6384051-B1 | ANTITUMOR AGENTS | AMERICAN CYANAMID COMPANY | 2002-05-07 | — | — | US | claimed |
| US-6002008-A | Substituted 3-cyano quinolines | AMERICAN CYANAMID COMPANY | 1999-12-14 | — | — | US | claimed |
| EP-1263503-A2 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | AMERICAN CYANAMID COMPANY (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001068186-A2 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | AMERICAN CYANAMID COMPANY (US) | 2001-09-20 | — | — | WO | disclosed |