Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.77 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.76 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.67 |
| ▸ | RAF1 | P04049 | 3/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382347 | 0.93 | EGFR (0.70) | EGFRERBB2MAP2K1RAF1PDE4B | |
| Hydrochloric Acid SCHEMBL6381171 | 0.92 | EGFR (0.70) | EGFRERBB2MAP2K1RAF1PDE4B | |
| SCHEMBL6381708 | 0.87 | EGFR (1.00) | EGFRERBB2MAP2K1RAF1SRC | |
| SCHEMBL6381476 | 0.86 | EGFR (0.75) | EGFRERBB2MAP2K1RAF1PDE4B | |
| SCHEMBL6381466 | 0.86 | EGFR (0.69) | EGFRERBB2MAP2K1RAF1PDE4B | |
| SCHEMBL8143917 | 0.86 | EGFR (0.69) | EGFRERBB2MAP2K1RAF1PDE4B | |
| SCHEMBL1893705 | 0.82 | PDE4B (0.71) | EGFRERBB2MAP2K1RAF1PDE4B | |
| SCHEMBL6380922 | 0.82 | PDE4B (0.71) | EGFRERBB2MAP2K1RAF1PDE4B | |
| SCHEMBL6426473 | 0.82 | EGFR (0.66) | EGFRERBB2GAK | |
| SCHEMBL6383741 | 0.82 | EGFR (0.63) | EGFRERBB2MAP2K1RAF1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-B1 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | WYETH CORP (US) | 2005-11-02 | — | — | EP | claimed |
| EP-0973746-B1 | SUBSTITUTED 3-CYANO QUINOLINES | WYETH CORP (US) | 2003-09-24 | — | — | EP | claimed |