Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.52 |
| ▸ | SRC | P12931 | 9/20 | 0.52 |
| ▸ | GAK | O14976 | 2/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383091 | 0.88 | EGFR (0.53) | EGFRSRCGAKERBB2MAP2K1 | |
| SCHEMBL6386079 | 0.88 | EGFR (0.67) | EGFRSRCGAKERBB2MAP2K1 | |
| SCHEMBL6380694 | 0.87 | EGFR (0.70) | EGFRSRCGAKERBB2MAP2K1 | |
| SCHEMBL6382800 | 0.85 | EGFR (0.56) | EGFRSRCGAKERBB2MAP2K1 | |
| SCHEMBL6384299 | 0.84 | EGFR (0.69) | EGFRSRCGAKERBB2MAP2K1 | |
| SCHEMBL6381073 | 0.84 | EGFR (0.69) | EGFRSRCGAKERBB2MAP2K1 | |
| SCHEMBL6386187 | 0.83 | EGFR (0.69) | EGFRGAKERBB2 | |
| SCHEMBL6381517 | 0.82 | EGFR (0.53) | EGFRSRCGAKERBB2MAP2K1 | |
| SCHEMBL6382227 | 0.82 | EGFR (0.70) | EGFRSRCGAKERBB2MAP2K1 | |
| SCHEMBL6379913 | 0.81 | EGFR (0.65) | EGFRSRCGAKERBB2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-B1 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | WYETH CORP (US) | 2005-11-02 | — | — | EP | claimed |
| EP-0973746-B1 | SUBSTITUTED 3-CYANO QUINOLINES | WYETH CORP (US) | 2003-09-24 | — | — | EP | claimed |