Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749549 | 0.88 | HSD17B10 (0.52) | KDM4ERAB9APTGER4KMT2ANPC1 | |
| SCHEMBL31085038 | 0.88 | KDM4E (0.50) | KDM4ERAB9AKMT2AMAPTNPC1 | |
| SCHEMBL1543013 | 0.82 | TDP1 (0.45) | KDM4ERAB9AKMT2AMAPTNPC1 | |
| SCHEMBL19023458 | 0.81 | BRD4 (0.44) | KDM4ERAB9AKMT2AMAPTNPC1 | |
| SCHEMBL1731129 | 0.80 | KDM4E (1.00) | KDM4ERAB9APTGER4KMT2AMAPT | |
| SCHEMBL638300 | 0.80 | RPS6KA5 (0.45) | KDM4ERAB9AKMT2ANPC1 | |
| SCHEMBL3534595 | 0.79 | KDM4E (0.45) | KDM4ERAB9APTGER4NPC1TSHR | |
| SCHEMBL31085125 | 0.79 | NPC1 (0.44) | KDM4ERAB9APTGER4KMT2AMAPT | |
| SCHEMBL2750918 | 0.79 | NPC1 (0.44) | KDM4EPTGER4KMT2AMAPTNPC1 | |
| SCHEMBL5329810 | 0.79 | KDM4E (0.44) | KDM4ERAB9APTGER4NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119648-B2 | Arthritis, obesity, (non-insulin dependent) diabetes calcitonin-induced osteoporosis; administering allograft transplantation; dipeptidyl peptidase-IV (DPP-IV) inhibitors | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2012-02-21 | — | — | US | disclosed |