SCHEMBL6384145

SCHEMBL6384145

Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC(C)(C(=O)O)c2cccs2)cc1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 20/20 0.67
PPARG P37231 16/20 0.67
PPARD Q03181 11/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6382725 0.92 PPARA (0.62) PPARAPPARGPPARD
SCHEMBL6382177 0.87 PPARA (0.74) PPARAPPARGPPARD
SCHEMBL6386527 0.85 PPARA (0.66) PPARAPPARGPPARD
SCHEMBL6277145 0.84 PPARA (0.75) PPARAPPARGPPARD
SCHEMBL6277149 0.84 PPARA (0.75) PPARAPPARGPPARD
SCHEMBL7903440 0.84 PPARA (0.78) PPARAPPARGPPARD
SCHEMBL6383130 0.84 PPARA (0.78) PPARAPPARGPPARD
SCHEMBL6384807 0.81 PPARA (0.68) PPARAPPARGPPARD
SCHEMBL5113930 0.81 PPARA (1.00) PPARAPPARGPPARD
SCHEMBL5113061 0.81 PPARA (1.00) PPARAPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030171377-A1 Antidiabetic agents BIGGE CHRISTOPHER FRANKLIN (US) 2003-09-11 US claimed
EP-1577305-A1 Oral antidiabetic agents WARNER-LAMBERT COMPANY LLC (US) 2005-09-21 EP disclosed
EP-1423363-A1 ORAL ANTIDIABETIC AGENTS Warner-Lambert Company LLC (US) 2004-06-02 EP disclosed
US-20030171377-A1 Antidiabetic agents BIGGE CHRISTOPHER FRANKLIN (US) 2003-09-11 US disclosed
WO-2003018553-A1 ORAL ANTIDIABETIC AGENTS WARNER-LAMBERT COMPANY LLC (US) 2003-03-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030171377-A1 Antidiabetic agents SLC5A1, SLC5A2, GLP1R PPARA 439/4885PPARG 280/4885PPARD 211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.