Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846837 | 0.93 | TRPV1 (0.56) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL846167 | 0.89 | TRPV1 (0.59) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL1577038 | 0.87 | TRPV1 (0.76) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL846784 | 0.86 | MEN1 (0.61) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL846333 | 0.86 | TRPV1 (0.74) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL846227 | 0.80 | TRPV1 (0.61) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL13991505 | 0.80 | MEN1 (0.67) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL20509078 | 0.80 | HDAC1 (0.76) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL13991492 | 0.80 | HDAC1 (0.72) | TRPV1MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL845900 | 0.80 | TRPV1 (0.72) | TRPV1MEN1KMT2AHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-12-14 | — | — | EP | claimed |
| WO-2004069792-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (US) | 2004-08-19 | — | — | WO | claimed |