Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | MITF | O75030 | 1/20 | 0.71 |
| ▸ | XBP1 | P17861 | 1/20 | 0.71 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.71 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.71 |
| ▸ | TRPV1 | Q8NER1 | 15/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846311 | 0.86 | TRPV1 (0.74) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL995474 | 0.86 | KDR (1.00) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL13991569 | 0.84 | NPC1 (0.70) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846578 | 0.84 | TRPV1 (0.67) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL845892 | 0.83 | KDR (0.70) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846216 | 0.83 | NPC1 (1.00) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL847083 | 0.83 | KDR (0.84) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846054 | 0.82 | TRPV1 (0.74) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846453 | 0.82 | TRPV1 (1.00) | KDRNPC1RAB9AKDM4EMITF | |
| SCHEMBL846874 | 0.82 | NPC1 (0.78) | KDRNPC1RAB9AKDM4EMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004069792-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (US) | 2004-08-19 | — | — | WO | disclosed |