Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 7/20 | 0.55 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384516 | 0.89 | EGFR (0.54) | STK4EGFRERBB2MAP2K1SRC | |
| SCHEMBL6383793 | 0.87 | EGFR (0.58) | STK4EGFRERBB2SRC | |
| SCHEMBL6383932 | 0.87 | EGFR (0.70) | EGFRERBB2 | |
| SCHEMBL6382237 | 0.87 | EGFR (0.58) | STK4EGFRERBB2SRC | |
| SCHEMBL6386029 | 0.84 | EGFR (0.61) | STK4EGFRERBB2SRC | |
| SCHEMBL6382030 | 0.82 | MAP2K1 (0.55) | STK4EGFRERBB2MAP2K1SRC | |
| SCHEMBL6379852 | 0.81 | EGFR (0.69) | STK4EGFRERBB2 | |
| SCHEMBL6385998 | 0.81 | EGFR (0.69) | EGFRERBB2SRC | |
| SCHEMBL6997292 | 0.81 | EGFR (0.46) | STK4EGFRERBB2SRC | |
| SCHEMBL6384070 | 0.81 | EGFR (0.71) | STK4EGFRERBB2MAP2K1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-B1 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | WYETH CORP (US) | 2005-11-02 | — | — | EP | claimed |
| EP-0973746-B1 | SUBSTITUTED 3-CYANO QUINOLINES | WYETH CORP (US) | 2003-09-24 | — | — | EP | claimed |