Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386666 | 0.86 | TRPV1 (0.44) | KDRTRPV1FLT1 | |
| SCHEMBL6384540 | 0.79 | TRPV1 (0.61) | KDRTRPV1FLT1 | |
| SCHEMBL6386387 | 0.79 | TRPV1 (0.60) | KDRTRPV1FLT1 | |
| SCHEMBL6384391 | 0.78 | TRPV1 (0.55) | KDRTRPV1FLT1 | |
| SCHEMBL6383904 | 0.78 | TRPV1 (0.51) | KDRTRPV1FLT1 | |
| SCHEMBL6388262 | 0.77 | TRPV1 (0.54) | KDRTRPV1FLT1 | |
| SCHEMBL6384014 | 0.77 | TRPV1 (0.54) | KDRTRPV1FLT1 | |
| SCHEMBL6383970 | 0.77 | TRPV1 (0.54) | KDRTRPV1FLT1 | |
| SCHEMBL6382791 | 0.77 | TRPV1 (0.54) | KDRTRPV1FLT1 | |
| SCHEMBL6386207 | 0.76 | TRPV1 (0.55) | KDRTRPV1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004069792-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (US) | 2004-08-19 | — | — | WO | disclosed |