Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.62 |
| ▸ | KDR | P35968 | 12/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.62 |
| ▸ | FLT1 | P17948 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | STK25 | O00506 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | CHUK | O15111 | 1/20 | 0.62 |
| ▸ | MUSK | O15146 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.62 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14796260 | 0.92 | FGFR1 (0.55) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL3382614 | 0.88 | PDGFRB (0.61) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL3802988 | 0.86 | FGFR1 (0.67) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL13255626 | 0.84 | PDGFRB (0.69) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL14795926 | 0.83 | FGFR1 (0.75) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL13041481 | 0.83 | FGFR1 (0.62) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL1055142 | 0.83 | FGFR1 (0.66) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL3381940 | 0.83 | FGFR1 (0.70) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL6389584 | 0.82 | PDGFRB (0.51) | PDGFRBFGFR1KDRCHEK2CHEK1 | |
| SCHEMBL13041478 | 0.82 | FGFR1 (0.63) | PDGFRBFGFR1KDRCHEK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100526312-C | Benzimidazole quinolinones and uses thereof | CHIRON CORP (US) | 2009-08-12 | — | — | CN | disclosed |
| CN-1692112-A | Benzimidazole quinolinones and uses thereof | CHIRON CORP (US) | 2005-11-02 | — | — | CN | disclosed |
| WO-2005054183-A2 | QUINOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005053692-A1 | ADVANCED QUINOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-06-16 | — | — | WO | disclosed |
| CN-1483028-A | Quinolinone derivatives as tyrosine kinase inhibitors | ϣ | 2004-03-17 | — | — | CN | disclosed |