Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386842 | 0.87 | TRPV1 (0.49) | TRPV1KDRFLT1RXFP1NPC1 | |
| SCHEMBL6385413 | 0.83 | TRPV1 (0.60) | TRPV1KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6385099 | 0.81 | TRPV1 (0.57) | TRPV1KDRFLT1RXFP1NPC1 | |
| SCHEMBL6384012 | 0.79 | KDR (0.46) | TRPV1KDRFLT1RXFP1NPC1 | |
| SCHEMBL6384010 | 0.78 | TRPV1 (0.58) | TRPV1KDRFLT1NPC1RAB9A | |
| SCHEMBL6384252 | 0.77 | TRPV1 (0.48) | TRPV1KDR | |
| SCHEMBL846053 | 0.73 | TRPV1 (0.70) | TRPV1KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6384011 | 0.73 | TRPV1 (0.48) | TRPV1KDRFLT1NPC1RAB9A | |
| SCHEMBL847627 | 0.73 | TRPV1 (0.62) | TRPV1KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6382503 | 0.72 | TRPV1 (0.51) | TRPV1KDRFLT1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-12-14 | — | — | EP | claimed |
| WO-2004069792-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (US) | 2004-08-19 | — | — | WO | claimed |