Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 3/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528429 | 0.99 | TDP1 (0.47) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6386887 | 0.92 | TDP1 (0.48) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL528667 | 0.92 | TDP1 (0.46) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL529241 | 0.91 | TDP1 (0.45) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL528377 | 0.91 | TDP1 (0.45) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7250262 | 0.91 | TDP1 (0.48) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL18039230 | 0.90 | TDP1 (0.44) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL527944 | 0.89 | CETP (0.45) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL528595 | 0.89 | TDP1 (0.46) | TDP1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL528492 | 0.89 | TDP1 (0.46) | TDP1LMNASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603553-A2 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | JAPAN TOBACCO INC. (JP) | 2005-12-14 | — | — | EP | claimed |
| WO-2004082593-A2 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | JAPAN TOBACCO INC. (JP) | 2004-09-30 | — | — | WO | claimed |