Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.66 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR1E | P28566 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6396123 | 0.94 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6393172 | 0.91 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6401997 | 0.86 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6095607 | 0.83 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6095615 | 0.83 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6904825 | 0.82 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6393200 | 0.80 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK1 | |
| SCHEMBL6402814 | 0.80 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6651799 | 0.80 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6402344 | 0.79 | MAPK14 (0.86) | MAPK14MAPK13MAPK12MAPK11AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897236-B1 | Aminobenzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS, LTD. (DK) | 2005-05-24 | — | — | US | claimed |
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | claimed |
| US-6897236-B1 | Aminobenzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS, LTD. (DK) | 2005-05-24 | — | — | US | disclosed |
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |