⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18827718 | 0.78 | — | — | |
| SCHEMBL7971977 | 0.77 | HSD17B10 (0.35) | — | |
| SCHEMBL27383307 | 0.77 | HSD17B10 (0.35) | — | |
| SCHEMBL55052 | 0.77 | — | — | |
| SCHEMBL4919959 | 0.77 | HSD17B10 (0.35) | — | |
| SCHEMBL1170204 | 0.76 | HSD17B10 (0.37) | — | |
| SCHEMBL29129891 | 0.74 | HSD17B10 (0.36) | — | |
| SCHEMBL716147 | 0.74 | HSD17B10 (0.52) | — | |
| SCHEMBL76862 | 0.74 | — | — | |
| SCHEMBL8437357 | 0.74 | HSD17B10 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107761192-B | Conductive elastic fiber and preparation method thereof | 上海益弹新材料有限公司 | 2020-05-01 | — | — | CN | claimed |
| CN-107779989-B | Composite elastic fiber and preparation method thereof | 上海益弹新材料有限公司 | 2019-12-13 | — | — | CN | claimed |
| EP-3567040-B1 | METHOD FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF [1,2,4]-TRIAZOLO[4,3-A]PYRIDINES | AMGEN INC (US) | 2020-09-09 | — | — | EP | disclosed |
| CN-111212884-A | Cold-sensitive composition containing 2,2, 6-trimethylcyclohexanecarboxylic acid derivative | 高砂香料工业株式会社 | 2020-05-29 | — | — | CN | disclosed |
| EP-3567040-A1 | METHOD FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF [1,2,4]-TRIAZOLO[4,3-A]PYRIDINES | Amgen, Inc (US) | 2019-11-13 | — | — | EP | disclosed |
| EP-3013825-B1 | METHOD FOR THE PREPARATION OF (1,2,4)-TRIAZOLO(4,3-A)PYRIDINES | AMGEN INC (US) | 2019-08-07 | — | — | EP | disclosed |
| US-9440979-B2 | Process for the preparation of pralatrexate | FRESENIUS KABI ONCOLOGY LIMITED (IN) | 2016-09-13 | — | — | US | disclosed |
| EP-3013825-A2 | METHOD FOR THE PREPARATION OF (1,2,4)-TRIAZOLO(4,3-A)PYRIDINES | Amgen Inc. (US) | 2016-05-04 | — | — | EP | disclosed |
| US-20150183789-A1 | IMPROVED PROCESS FOR THE PREPARATION OF PRALATREXATE | FRESENIUS KABI ONCOLOGY LIMITED (IN) | 2015-07-02 | — | — | US | disclosed |
| WO-2014210042-A2 | METHOD FOR THE PREPARATION OF (1,2,4)-TRIAZOLO(4,3-A)PYRIDINES | AMGEN INC. (US) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014016740-A2 | IMPROVED PROCESS FOR THE PREPARATION OF PRALATREXATE | FRESENIUS KABI ONCOLOGY LTD. (IN) | 2014-01-30 | — | — | WO | disclosed |
| US-5403852-A | Antiinflammatory agents | LABORATOIRE ROGER BELLON (FR) | 1995-04-04 | — | — | US | disclosed |
| US-5151160-A | Distillation of a mixture and extraction with a solvent | Berg, Lloyd (US) | 1992-09-29 | — | — | US | disclosed |
| US-4886794-A | ANTIHISTAMINES, ANTIALLERGENS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-12-12 | — | — | US | disclosed |
| US-4880820-A | VIRICIDES, HERPES VIRUS | MERCK & CO., INC. (US) | 1989-11-14 | — | — | US | disclosed |
| EP-0291244-A1 | Cyclic carbamate derivatives | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4713383-A | ADENOSINE AND BENZODIAZEPINE ANTAGONISTS | CIBA-GEIGY CORPORATION (US) | 1987-12-15 | — | — | US | disclosed |
| EP-0130126-B1 | (S)-9-(2,3-DIHYDROXY-1-PROPOXYMETHYL) GUANINE AND ITS ACYL DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ANTIHERPETIC AGENTS | MERCK & CO. INC. (US) | 1987-08-26 | — | — | EP | disclosed |
| EP-0130126-A1 | (S)-9-(2,3-dihydroxy-1-propoxymethyl) guanine and its acyl derivatives, their preparation and their application as antiherpetic agents | MERCK & CO. INC. (US) | 1985-01-02 | — | — | EP | disclosed |
| US-4366189-A | WHITENERS | CIBA-GEIGY CORPORATION (US) | 1982-12-28 | — | — | US | disclosed |