Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 18/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 18/20 | 0.63 |
| ▸ | KDR | P35968 | 18/20 | 0.63 |
| ▸ | EGFR | P00533 | 9/20 | 0.63 |
| ▸ | SRC | P12931 | 4/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | STK4 | Q13043 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404719 | 0.81 | FGFR1 (0.77) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL6404712 | 0.81 | FGFR1 (0.77) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL6397137 | 0.80 | PDGFRB (0.59) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL6397131 | 0.80 | PDGFRB (0.59) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL6405974 | 0.78 | PDGFRB (0.69) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL4410831 | 0.78 | KDR (1.00) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL4410833 | 0.78 | KDR (1.00) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL6390542 | 0.75 | PDGFRB (0.77) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL6390545 | 0.75 | PDGFRB (0.77) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL6392692 | 0.74 | FGFR1 (1.00) | PDGFRBFGFR1KDREGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878733-B1 | Formulations for pharmaceutical agents ionizable as free acids or free bases | SUGEN, INC. (US) | 2005-04-12 | — | — | US | disclosed |