Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.68 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18264880 | 1.00 | PTPN1 (0.68) | PTPN1NR1H2HDAC8MMP8MMP3 | |
| SCHEMBL998296 | 0.88 | NR1H2 (0.60) | PTPN1NR1H2HDAC8MMP8MMP3 | |
| SCHEMBL8489101 | 0.88 | NR1H2 (0.60) | PTPN1NR1H2HDAC8MMP8MMP3 | |
| SCHEMBL6393250 | 0.87 | PTPN1 (0.69) | PTPN1NR1H2HDAC8 | |
| SCHEMBL2895743 | 0.87 | PTPN1 (0.69) | PTPN1HDAC8 | |
| SCHEMBL18929509 | 0.87 | PTPN1 (0.69) | PTPN1NR1H2HDAC8 | |
| SCHEMBL17486413 | 0.87 | PTPN1 (0.69) | PTPN1HDAC8 | |
| SCHEMBL30592013 | 0.87 | PTPN1 (0.69) | PTPN1HDAC8 | |
| SCHEMBL29369360 | 0.87 | PTPN1 (0.69) | PTPN1HDAC8 | |
| SCHEMBL1202386 | 0.87 | PTPN1 (0.69) | PTPN1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154011-A1 | Tetrahydroisoquinolnyl sulfamic acids | THE PROCTER & GAMBLE COMPANY | 2005-07-14 | — | — | US | disclosed |
| WO-2004074256-A1 | TETRAHYDROISOQUINOLINYL SULFAMIC ACIDS | THE PROCTER & GAMBLE COMPANY (US) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154011-A1 | Tetrahydroisoquinolnyl sulfamic acids | PTPRS, PTPRJ, PTPRM | PTPN1 9/4885NR1H2 1664/4885HDAC8 3912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.