Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 14/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6399419 | 1.00 | LSS (0.42) | LSSNLRP3MAPTHRH3MEN1 | |
| SCHEMBL6404928 | 0.94 | LSS (0.42) | LSSMAPTMEN1KMT2A | |
| SCHEMBL5639435 | 0.93 | MAPT (0.46) | LSSMAPTHRH3 | |
| SCHEMBL5637636 | 0.93 | MAPT (0.46) | LSSMAPTHRH3 | |
| SCHEMBL6404485 | 0.92 | LSS (0.51) | LSSMEN1KMT2A | |
| SCHEMBL6399626 | 0.92 | LSS (0.50) | LSSMAPTHRH3MEN1KMT2A | |
| SCHEMBL6398710 | 0.92 | LSS (0.46) | LSSMAPTHRH3MEN1KMT2A | |
| SCHEMBL6404168 | 0.92 | LSS (0.51) | LSSMEN1KMT2A | |
| SCHEMBL6406661 | 0.92 | LSS (0.46) | LSSMAPTHRH3MEN1KMT2A | |
| SCHEMBL5638357 | 0.92 | LSS (0.48) | LSSHRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |