SCHEMBL6400612 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	16/20	0.61

▸	PSEN2	P49810	16/20	0.61

▸	APH1B	Q8WW43	16/20	0.61

▸	NCSTN	Q92542	16/20	0.61

▸	APH1A	Q96BI3	16/20	0.61

▸	PSENEN	Q9NZ42	16/20	0.61

▸	KMT2A	Q03164	1/20	0.40

▸	TP53	P04637	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6394944	0.95	PSEN1 (0.68)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6396844	0.89	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6395153	0.89	PSEN1 (0.63)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6391578	0.88	PSEN1 (0.62)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6392568	0.88	PSEN1 (0.64)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6393709	0.87	PSEN1 (0.61)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6399508	0.87	PSEN1 (0.61)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6393499	0.86	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6393642	0.86	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6393312	0.86	PSEN1 (0.59)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6967196-B1	Sulfonamide compounds and uses thereof	BRISTOL-MYERS SQUIBB COMPANY (US)	2005-11-22	—	—	US	disclosed