Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 5/20 | 0.52 |
| ▸ | RBPJ | Q06330 | 4/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.47 |
| ▸ | APP | P05067 | 9/20 | 0.42 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485603 | 1.00 | NOTCH1 (0.52) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4483056 | 0.96 | PSEN1 (0.51) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL5645437 | 0.92 | NOTCH1 (0.43) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4482439 | 0.92 | NOTCH1 (0.43) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4488978 | 0.91 | NOTCH1 (0.42) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4487715 | 0.91 | PSEN1 (0.43) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL5921870 | 0.91 | PSEN1 (0.43) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4497054 | 0.91 | PSEN1 (0.58) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4498962 | 0.89 | NOTCH1 (0.52) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4500915 | 0.89 | NOTCH1 (0.53) | NOTCH1RBPJPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245501-A1 | Succinoylamino lactams as inhibitors of A-beta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-11-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245501-A1 | Succinoylamino lactams as inhibitors of A-beta protein production | BACE1, APH1A, APP | NOTCH1 94/4885RBPJ 1902/4885PSEN1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.