Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.61 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.56 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.56 |
| ▸ | PREP | P48147 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667340 | 1.00 | DPP4 (0.61) | DPP4DPP8DPP7PREP | |
| SCHEMBL667339 | 1.00 | DPP4 (0.61) | DPP4DPP8DPP7PREP | |
| SCHEMBL664190 | 0.84 | DPP4 (0.63) | DPP4DPP8DPP7PREP | |
| SCHEMBL664189 | 0.84 | DPP4 (0.63) | DPP4DPP8DPP7PREP | |
| SCHEMBL666773 | 0.80 | DPP4 (0.58) | DPP4DPP8DPP7PREP | |
| SCHEMBL666772 | 0.80 | DPP4 (0.58) | DPP4DPP8DPP7PREP | |
| SCHEMBL666567 | 0.79 | DPP4 (0.69) | DPP4DPP8DPP7PREP | |
| SCHEMBL666568 | 0.79 | DPP4 (0.69) | DPP4DPP8DPP7PREP | |
| SCHEMBL665630 | 0.77 | DPP4 (0.79) | DPP4DPP8DPP7PREP | |
| SCHEMBL1436910 | 0.77 | DPP4 (0.79) | DPP4DPP8DPP7PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861440-B2 | DPP IV inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20030130281-A1 | DPP IV inhibitors | HOFFMAN-LA ROCHE INC. | 2003-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130281-A1 | DPP IV inhibitors | DPP4, DPP3, DPP7 | DPP4 1/4885DPP8 6/4885DPP7 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.