Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.39 |
| ▸ | RELA | Q04206 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5638204 | 0.91 | TP53 (0.49) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL6400266 | 0.90 | MAPT (0.46) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL6404170 | 0.90 | LSS (0.43) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL6400584 | 0.90 | MAPT (0.51) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL5637808 | 0.87 | SMN1; SMN2 (0.43) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL6405963 | 0.86 | LSS (0.48) | MAOBLSSMEN1KMT2A | |
| SCHEMBL5637681 | 0.82 | LSS (0.40) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL6403158 | 0.82 | LSS (0.40) | RAB9ATP53MAPTPOLBLMNA | |
| SCHEMBL5637474 | 0.81 | S1PR1 (0.38) | TP53LMNALSS | |
| SCHEMBL5637812 | 0.81 | KDM4E (0.41) | TP53MAPTPOLBLMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020624-A1 | Dihydroindole and tetrahydroquinoline derivatives | AEBI JOHANNES (CH) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020624-A1 | Dihydroindole and tetrahydroquinoline derivatives | CYP46A1, LSS, CYP51A1 | RAB9A 1287/4885SMN1; SMN2 4761/4885NPC1 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.