Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 17/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5635983 | 0.95 | LSS (0.44) | LSSMAPTMEN1KMT2A | |
| SCHEMBL6406661 | 0.94 | LSS (0.46) | LSSMAPTMEN1KMT2A | |
| SCHEMBL6398710 | 0.94 | LSS (0.46) | LSSMAPTMEN1KMT2A | |
| SCHEMBL5637542 | 0.92 | LSS (0.44) | LSSMAPTMEN1KMT2A | |
| SCHEMBL6404928 | 0.92 | LSS (0.42) | LSSMAPTMEN1KMT2A | |
| SCHEMBL6405618 | 0.91 | LSS (0.51) | LSSMEN1KMT2A | |
| SCHEMBL5637928 | 0.91 | LSS (0.48) | LSS | |
| SCHEMBL6406541 | 0.90 | CACNA1H (0.44) | LSSMEN1KMT2A | |
| SCHEMBL6399404 | 0.90 | LSS (0.43) | LSSMEN1KMT2A | |
| SCHEMBL5637636 | 0.86 | MAPT (0.46) | LSSMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020624-A1 | Dihydroindole and tetrahydroquinoline derivatives | AEBI JOHANNES (CH) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020624-A1 | Dihydroindole and tetrahydroquinoline derivatives | CYP46A1, LSS, CYP51A1 | LSS 2/4885MAPT 3562/4885NPC1 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.