Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 18/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 18/20 | 0.79 |
| ▸ | EGFR | P00533 | 9/20 | 0.79 |
| ▸ | SRC | P12931 | 5/20 | 0.71 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404870 | 1.00 | KDR (0.79) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL6406332 | 0.92 | KDR (0.74) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL6406330 | 0.92 | KDR (0.74) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL6406432 | 0.90 | KDR (0.76) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL6406433 | 0.90 | KDR (0.76) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL4408645 | 0.88 | KDR (1.00) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL4408641 | 0.88 | KDR (1.00) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL6405120 | 0.85 | KDR (0.65) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL6405124 | 0.85 | KDR (0.65) | KDRPDGFRBFGFR1EGFRSRC | |
| SCHEMBL6396784 | 0.85 | PDGFRB (1.00) | KDRPDGFRBFGFR1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855730-B2 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040067531-A1 | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds | SUGEN, INC. | 2004-04-08 | — | — | US | disclosed |
| US-20040024010-A1 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. | 2004-02-05 | — | — | US | disclosed |
| US-6531502-B1 | Antitumor | SUGEN, INC. | 2003-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067531-A1 | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds | ABL1, LCK, PNCK | KDR 634/4885PDGFRB 622/4885FGFR1 985/4885 |
| US-20040024010-A1 | 3-methylidenyl-2-indolinone modulators of protein kinase | DMPK, MAP4K3, MAP3K20 | KDR 1617/4885PDGFRB 1860/4885FGFR1 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.