Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 4/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KIF11 | P52732 | 4/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ME2 | P23368 | 1/20 | 0.35 |
| ▸ | ME1 | P48163 | 1/20 | 0.35 |
| ▸ | ME3 | Q16798 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11555218 | 0.75 | ESR2 (0.55) | MAPTKMT2AESR1ESR2ALDH1A1 | |
| SCHEMBL11528914 | 0.72 | CYP2C19 (0.40) | MAPTKMT2AALDH1A1CYP3A4KIF11 | |
| SCHEMBL6788454 | 0.72 | MEN1 (0.39) | MAPTKMT2AESR1ESR2ALDH1A1 | |
| SCHEMBL12640844 | 0.70 | ESR2 (0.48) | ESR1ESR2ALDH1A1CYP3A4CHRM3 | |
| SCHEMBL6405071 | 0.70 | HDAC3 (0.58) | MAPTKMT2AKCNN4CYP2C19HIF1A | |
| SCHEMBL3381757 | 0.70 | SLC22A12 (0.50) | ESR1ESR2ALDH1A1CYP3A4BLM | |
| Phenol SCHEMBL28224533 | 0.69 | MAPT (0.54) | MAPTKMT2AESR1ESR2ALDH1A1 | |
| SCHEMBL12640848 | 0.68 | ESR1 (0.46) | ESR1ESR2ALDH1A1CYP3A4KIF11 | |
| Bicarbonate SCHEMBL23683863 | 0.67 | ESR1 (0.87) | MAPTKMT2AESR1ESR2ALDH1A1 | |
| Bicarbonate SCHEMBL19723102 | 0.67 | ESR1 (0.87) | MAPTKMT2AESR1ESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050196819-A1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS PHARMACEUTICALS, INC. | 2005-09-08 | — | — | US | disclosed |
| US-6887712-B1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS, INC. (US) | 2005-05-03 | — | — | US | disclosed |