Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6407850 | 0.97 | PARP1 (1.00) | PARP1 | |
| SCHEMBL6405272 | 0.89 | PARP1 (0.85) | PARP1SIGMAR1 | |
| SCHEMBL6405735 | 0.89 | PARP1 (0.85) | PARP1SIGMAR1 | |
| SCHEMBL6406376 | 0.87 | PARP1 (0.81) | PARP1SIGMAR1HTR1A | |
| SCHEMBL6410344 | 0.79 | PARP1 (0.68) | PARP1SIGMAR1HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL6404123 | 0.77 | PARP1 (0.98) | PARP1HTR1AMAPTDRD2DRD4 | |
| SCHEMBL6409099 | 0.77 | PARP1 (0.65) | PARP1SIGMAR1MAPT | |
| SCHEMBL6437727 | 0.76 | PARP1 (0.66) | PARP1CYP1A2CYP3A4HTR1AMAPT | |
| SCHEMBL6367272 | 0.75 | PARP1 (1.00) | PARP1SIGMAR1 | |
| SCHEMBL6367194 | 0.74 | PARP1 (0.98) | PARP1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171101-A1 | Phenanthridinones as parp inhibitors | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171101-A1 | Phenanthridinones as parp inhibitors | PARP1, PARP11, PARP2 | PARP1 1/4885SIGMAR1 1351/4885CYP1A2 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.