⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9432506 | 0.89 | — | — | |
| SCHEMBL1448244 | 0.85 | KCNH2 (0.32) | — | |
| SCHEMBL1240961 | 0.76 | — | — | |
| SCHEMBL28144960 | 0.73 | — | — | |
| SCHEMBL29098232 | 0.73 | — | — | |
| SCHEMBL1270009 | 0.72 | — | — | |
| SCHEMBL4276737 | 0.71 | — | — | |
| SCHEMBL11155231 | 0.69 | SLC18A3 (0.36) | — | |
| SCHEMBL23047083 | 0.69 | — | — | |
| SCHEMBL6114034 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2735567-B1 | HETEROCYCLIC SUBSTITUTED PYRIMIDINE COMPOUND | XUANZHU PHARMA CO LTD (CN) | 2016-10-26 | — | — | EP | disclosed |
| EP-2735567-A1 | HETEROCYCLIC SUBSTITUTED PYRIMIDINE COMPOUND | Xuanzhu Pharma Co., Ltd. (CN) | 2014-05-28 | — | — | EP | disclosed |
| US-6855730-B2 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040024010-A1 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. | 2004-02-05 | — | — | US | disclosed |
| US-6531502-B1 | Antitumor | SUGEN, INC. | 2003-03-11 | — | — | US | disclosed |
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000008202-A2 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN, INC. (US) | 2000-02-17 | — | — | WO | disclosed |