⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4529227 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4521838 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4530431 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4518246 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4516182 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4522669 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4528742 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4527976 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4527470 | 0.97 | TYMS (0.58) | — | |
| SCHEMBL4524401 | 0.97 | TYMS (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108373515-A | A kind of amphipathic RAFT reagents of phosphatic type trithiocarbonate and preparation method thereof | 陈晨特 | 2018-08-07 | — | — | CN | claimed |
| US-20240002416-A1 | MRGPRX4 Agonists and Antagonists | RHEINISCHE-FRIEDRICH-WILHELMS-UNIVERSITAT BONN (DE) | 2024-01-04 | — | — | US | disclosed |
| US-11777058-B2 | Light-emitting device and display apparatus including the same | SAMSUNG DISPLAY CO., LTD. (KR) | 2023-10-03 | — | — | US | disclosed |
| EP-4229059-A1 | 3-SUBSTITUTED XANTHINE DERIVATIVES AS MRGPRX4 RECEPTOR MODULATORS | Rheinische Friedrich-Wilhelms-Universität Bonn (DE) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022079245-A1 | 3-SUBSTITUTED XANTHINE DERIVATIVES AS MRGPRX4 RECEPTOR MODULATORS | RHEINISCHE-FRIEDRICH-WILHELMS-UNIVERSITÄT BONN (DE) | 2022-04-21 | — | — | WO | disclosed |
| US-20190119200-A1 | TERTIARY AMIDES AND METHOD OF USE | ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD. (CN) | 2019-04-25 | — | — | US | disclosed |
| CN-108373515-A | A kind of amphipathic RAFT reagents of phosphatic type trithiocarbonate and preparation method thereof | 陈晨特 | 2018-08-07 | — | — | CN | disclosed |
| WO-2017177004-A1 | TERTIARY AMIDES AND METHOD OF USE | ABBVIE INC. (US) | 2017-10-12 | — | — | WO | disclosed |
| US-20050026873-A1 | Type-I methionyl aminopeptidases inhibitors in antibacterial targeting | UTAH STATE UNIVERSITY | 2005-02-03 | — | — | US | disclosed |
| EP-0904262-B1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2004-04-21 | — | — | EP | disclosed |
| US-6472414-B1 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-29 | — | — | US | disclosed |
| US-5986042-A | Cross-linked polymer | MITSUI CHEMICALS, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0856539-A1 | Cross-linked polymer | Mitsui Chemicals, Inc. (JP) | 1998-08-05 | — | — | EP | disclosed |
| US-5760246-A | ANTILIPEMIC AGENTS, ANTICHOLESTEROL AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 1998-06-02 | — | — | US | disclosed |