SCHEMBL6410155

SCHEMBL6410155

CCSc1ncccc1C(=O)N1CCC2(CC1)CC(OC(=O)NCc1ccccc1)=NO2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
KMT2A Q03164 2/20 0.39
PKM P14618 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
FNTA P49354 1/20 0.38
FNTB P49356 1/20 0.38
ATM Q13315 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
MAPT P10636 1/20 0.36
HTT P42858 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CYP2C9 P11712 3/20 0.36
CYP3A4 P08684 2/20 0.36
CYP2C19 P33261 2/20 0.36
CYP46A1 Q9Y6A2 2/20 0.36
CYP2C8 P10632 1/20 0.36
ALDH1A1 P00352 3/20 0.36
CYP1A2 P05177 1/20 0.35
CHRM2 P08172 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2400710 0.86 ATM (0.43) HPGDRXFP1KMT2APKML3MBTL1
SCHEMBL6409707 0.84 MAPK8 (0.51) CYP2C9CYP3A4CYP2C19CYP46A1CYP2C8
SCHEMBL6409843 0.80 CYP3A4 (0.47) KMT2ACYP2C9CYP3A4CYP2C19ALDH1A1
SCHEMBL6410103 0.80 CYP2D6 (0.42) HPGDKMT2AMAPTALDH1A1ACHE
SCHEMBL6415557 0.80 KMT2A (0.45) HPGDKMT2AL3MBTL1ALDH1A1MEN1
SCHEMBL6410188 0.79 MEN1 (0.45) KMT2APKMMAPTHTTCYP2C19
SCHEMBL15309181 0.79 KMT2A (0.44) KMT2AL3MBTL1FNTAFNTBSMN1; SMN2
SCHEMBL6410565 0.77 CYP2D6 (0.51) HPGDKMT2ASMN1; SMN2MAPTCYP2C9
SCHEMBL6409864 0.77 KMT2A (0.43) HPGDKMT2ASMN1; SMN2MAPTHTT
SCHEMBL6410969 0.74 GRM5 (0.45) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401841-B1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN GRUENENTHAL GMBH (DE) 2005-08-24 EP claimed
EP-1401841-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2004-03-31 EP claimed
WO-2003000699-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2003-01-03 WO claimed
EP-1401841-B1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN GRUENENTHAL GMBH (DE) 2005-08-24 EP disclosed
EP-1401841-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2004-03-31 EP disclosed
WO-2003000699-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2003-01-03 WO disclosed