Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410166 | 0.86 | KDM4E (0.62) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL6409808 | 0.85 | SMN1; SMN2 (0.48) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL2400943 | 0.76 | KDM4E (0.50) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL2400849 | 0.76 | MEN1 (0.53) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL11623286 | 0.76 | SMN1; SMN2 (0.82) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL29040265 | 0.76 | SMN1; SMN2 (0.82) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL7756182 | 0.74 | SMN1; SMN2 (0.79) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL6667166 | 0.74 | SMN1; SMN2 (0.79) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL1298199 | 0.73 | SMN1; SMN2 (1.00) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 | |
| SCHEMBL6783522 | 0.72 | SMN1; SMN2 (0.75) | KDM4ESMN1; SMN2MEN1KMT2ACXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |